PERIOPERATIVE DIABETIC KETOACIDOSIS ASSOCIATED WITH SODIUM-GLUCOSE CO-TRANSPORTER-2 INHIBITORS : A SYSTEMATIC REVIEW

DKA or diabetic ketoacidosis is an emergency condition caused by hyperglycemia in which excessive acid produced the blood. Patients with type 1 and 2 diabetes who undergo surgery, have infection, are under extreme stress can also develop DKA. The body generates hormone adrenaline to combat infection stress, but this a negative effect on blood glucose levels (adrenaline counterinsulin). This worsen if patient refuses take medication inject insulin during stressful infectious situations. fundamental components of pathophysiological mechanisms at play (DKA) include shifts ensuing inflammatory response. Alterations concentration hormones lead production consumption glucose, as well increase lipolysis formation ketone bodies. Canagliflozin, dapagliflozin, empagliflozin, ertugliflozin agents approved Food Drug Administration (FDA) for treatment mellitus (DM) adults. Acting proteins, four SGLT2 inhibitor class agents. SGLT-2 expressed kidney's proximal tubule. may result decrease filtered reabsorption, renal threshold (RTG), excretion via urine. Diabetes patients treated sodium–glucose transport protein (SGLT2) inhibitors been reported experience results study indicate that uncommon among T2DM inhibitors.